CRISPR-Cas9 systems have been adapted as versatile gene-editing tools that have revolutionized the way we conduct basic science and created a billion dollar industry for therapeutics, agricultural products and diagnostic tools. And yet much remains unknown regarding how CRISPR-Cas9 systems function in nature, where they provide bacteria with adaptive immunity against bacterial viruses (bacteriophages) and other foreign genetic elements. Join a collaboration between the Bailey and Modell labs to better understand the native functions of Cas9 and its interactions with bacterial co-factors and bacteriophage antagonists combining genetic, molecular and biochemical approaches with cryo-EM.
Modell Lab & Bailey Lab