We investigate how the brain’s neocortex represents and sequentially updates hypotheses using the spatial computations that occur as rodents undertake natural behaviors. When mice behave naturally in complex environments, they maintain a working memory of what they’ve recently experienced, use this memory to interpret ambiguous cues, and plan ahead on timescales from seconds to hours. We want to use these computations to probe the neural mechanisms by which mammals can build and make use of models of their environment.
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